Tnfrsf4tm2(cre)Nik
Targeted Allele Detail
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Symbol: |
Tnfrsf4tm2(cre)Nik |
Name: |
tumor necrosis factor receptor superfamily, member 4; targeted mutation 2, Nigel Killeen |
MGI ID: |
MGI:3843034 |
Synonyms: |
Ox40-Cre |
Gene: |
Tnfrsf4 Location: Chr4:156098300-156101069 bp, + strand Genetic Position: Chr4, 87.68 cM
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Alliance: |
Tnfrsf4tm2(cre)Nik page
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Germline Transmission: |
Earliest citation of germline transmission:
J:147746
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Parent Cell Line: |
JM-1 (ES Cell)
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Strain of Origin: |
129X1/SvJ
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Allele Type: |
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Targeted (Recombinase) |
Mutation: |
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Insertion
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Tnfrsf4tm2(cre)Nik expression driven by
1 gene
Knock-in expression driven by:
Organism |
Driver Gene |
Note |
mouse |
Tnfrsf4 (MGI:104512) |
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Mutation details: 1.7 kb of the locus containing exons 1, 2 and part of 3 was fused to an IRES-cre construct followed by a FRT-flanked neomycin selection element. After targeted recombination, the neomycin element was removed by crossing founder mice with FLPe transgenic mice. Insertion of the cre expression construct disrupted the endogenous locus, creating a null allele. Cre expression was detected in male but not female germline cells, in memory and regulatory CD4+ T cells, and in some CD8+ and naive CD4+ T cells.
(J:147746)
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Activity: |
Tissue activity of this recombinase allele
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Driver:
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Tnfrsf4
(mouse)
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View phenotypes and curated references for all genotypes (concatenated display).
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Original: |
J:147746 Klinger M, et al., Thymic OX40 expression discriminates cells undergoing strong responses to selection ligands. J Immunol. 2009 Apr 15;182(8):4581-9 |
All: |
31 reference(s) |
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