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FlcnGt(RRX115)Byg
Gene trapped Allele Detail
Summary
Symbol: FlcnGt(RRX115)Byg
Name: folliculin; gene trap RRX115, BayGenomics
MGI ID: MGI:3842151
Synonyms: Bhd-
Gene: Flcn  Location: Chr11:59682234-59700842 bp, - strand  Genetic Position: Chr11, 37.79 cM
Alliance: FlcnGt(RRX115)Byg page
Mutation
origin
Mutant Cell Line:  RRX115
Germline Transmission:  Earliest citation of germline transmission: J:147582
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Gene trapped (Hypomorph)
Mutation:    Insertion of gene trap vector     Vector: pGT2Lxf     Vector Type: gene trap
 
Mutation details: A Beta-geo gene trap vector inserted into intron 8. Truncation of the transcript was confirmed by RT-PCR analysis of ES cells. Heterozygote mice only had half the expression of full-length mRNA as determined by Q-PCR on kidney lysates. (J:147582)
Sequence Tags: 
Sequence tag details (1 tag)
Genome Context: 
Genome Browser view of this mutation
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 64 assay results
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Flcn Mutation:  40 strains or lines available
Notes
All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.
References
Original:  J:147582 Hartman TR, et al., The role of the Birt-Hogg-Dube protein in mTOR activation and renal tumorigenesis. Oncogene. 2009 Apr 2;28(13):1594-604
All:  4 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory