Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
FlcnGt(RRX115)Byg mutation
(0 available);
any
Flcn mutation
(40 available)
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mortality/aging
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• no viable homozygotes after E7.5
• 25% of E6.5 embryos are severely abnormal or partially resorbed
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• no homozygous pups result from matings between heterozygotes
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embryo
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• distorted visceral endoderm and lacking cavitation at E6.5
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• grossly atrophied and disorganized egg cylinders at E6.5
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Allelic Composition |
FlcnGt(RRX115)Byg/Flcn+
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Genetic Background |
involves: 129P2/OlaHsd * C57BL/6 |
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
FlcnGt(RRX115)Byg mutation
(0 available);
any
Flcn mutation
(40 available)
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renal/urinary system
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• 57% of mice at 3-6 months of age have renal cysts consisting of oncocytic cells with an average diameter of 0.4 mm
• a similar incidence of cysts is observed in older mice with an average diameter of 0.8 mm
• solid tumors consisting of oncocytic cells are observed in about 10% of mice
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• solid tumors consisting of oncocytic cells are observed in the kidneys of about 10% of mice
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neoplasm
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• mice subjected to ENU-treatment in utero have higher incidence of kidney cysts
• 94% of these mice develop kidney cysts by 5 months of age
• mice average 5.5 cysts per mouse with cysts ranging from 0.1 to 1.9 mm in diameter
• cysts are lined by oncocytic cells
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• is observed in older mice though incidence is similar to what is reported for C57BL/6 mice
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• solid tumors consisting of oncocytic cells are observed in the kidneys of about 10% of mice
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homeostasis/metabolism
growth/size/body
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• 57% of mice at 3-6 months of age have renal cysts consisting of oncocytic cells with an average diameter of 0.4 mm
• a similar incidence of cysts is observed in older mice with an average diameter of 0.8 mm
• solid tumors consisting of oncocytic cells are observed in about 10% of mice
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