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Id2tm1Mais
Targeted Allele Detail
Summary
Symbol: Id2tm1Mais
Name: inhibitor of DNA binding 2; targeted mutation 1, Mark A Israel
MGI ID: MGI:3838359
Synonyms: Id2tm1Jdu
Gene: Id2  Location: Chr12:25143798-25146091 bp, - strand  Genetic Position: Chr12, 8.57 cM, cytoband B
Alliance: Id2tm1Mais page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:146624
Parent Cell Line:  JM-1 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsA targeting vector containing the neomycin resistance cassette was used to replace a region 560 bp 5' upstream of the transcription start site and exons 1 and 2 using homologous recombination. Exons 1-2 encode the entire coding domain. Western blot and immunoprecipitation of xx tissues confirmed that no protein was expressed in mutant mice. Western blot analysis of liver tissues confirmed that no protein was expressed in mutant mice. (J:146624)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Id2 Mutation:  19 strains or lines available
References
Original:  J:146624 Duffield GE, et al., A role for Id2 in regulating photic entrainment of the mammalian circadian system. Curr Biol. 2009 Feb 24;19(4):297-304
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory