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Gene Expression Data
Assay Details
Assay
Reference: J:15320 Lyons KM, et al., Patterns of expression of murine Vgr-1 and BMP-2a RNA suggest that transforming growth factor-beta-like genes coordinately regulate aspects of embryonic development. Genes Dev. 1989 Nov;3(11):1657-68
Assay type: RNA in situ
MGI Accession ID: MGI:3837695
Gene symbol: Bmp6
Gene name: bone morphogenetic protein 6
Probe: Bmp6 cDNA7
Probe preparation: Antisense labelled with S35 RNA
Visualized with: Autoradiography
Results
Specimen 1A,B: postnatal adult (more )
Structure Level Pattern Image Note
TS28: oocyte Strong 1A/B High levels of expression in both immature and mature oocytes.
TS28: ovary follicle Weak Regionally restricted 1A/B Much lower level of expression in somatic follicle cells surrounding the developing oocytes.
TS28: ovary stratum granulosum Trace 1A/B Little or no signal seen in the granulosa or thecal cells.
TS28: ovary theca Trace 1A/B Little or no signal seen in the granulosa or thecal cells.
TS28: cumulus oophorus Absent 1A/B Little or no signal seen in the granulosa or thecal cells.
TS28: oviduct Absent 1A/B Little or no signal seen in the granulosa or thecal cells.

Specimen 1C,D: embryonic day 0.5 (more )
Note: Section through two fertilized one-cell eggs.
Structure Level Pattern Image Note
TS1: 1-cell stage embryo Present 1C/D Authors report lower expression in fertilized eggs than in oocytes.

Specimen not shown 2-cell: embryonic day 1.0 (more )
Structure Level Pattern Image Note
TS2: 2-cell stage embryo Absent

Specimen 1F,G: embryonic day 2.0 (more )
Note: Authors describe specimen as a three- or four-cell-stage embryo.
Structure Level Pattern Image Note
TS3: 4-cell stage embryo Absent 1F/G

Specimen not shown 8-cell: embryonic day 3.0 (more )
Structure Level Pattern Image Note
TS3: 8-cell stage embryo Absent

Specimen not shown 16-cell: embryonic day 3.0 (more )
Structure Level Pattern Image Note
TS3: compacted morula Absent

Specimen 1H,I: embryonic day 4.5 (more )
Structure Level Pattern Image Note
TS5: inner cell mass Weak 1H/I Low level of expression in the inner cell mass.

Specimen 2A,B: embryonic day 12.5 (more )
Note: Section through dorsal skin.
Structure Level Pattern Image Note
TS21: skin Absent 2A/B No expression in epidermis or dermis.

Specimen 2C,D: embryonic day 15.5 (more )
Note: Section through dorsal skin.
Structure Level Pattern Image Note
TS23: epidermis Strong Regionally restricted 2C/D Strong expression in the suprabasal layers of the epidermis.
TS23: dermis Absent 2C/D
TS23: hair follicle Absent 2C/D

Specimen 2G,H: embryonic day 16.5 (more )
Note: Section through the upper snout.
Structure Level Pattern Image Note
TS24: epidermis Strong Regionally restricted 2G/H
TS24: palate epithelium Weak Regionally restricted 2G/H Lower levels of expression confined to the uppermost layers of epithelium in the palate.

Specimen 2I,J: embryonic day 16.5 (more )
Note: Enlargement of upper boxed region in 2G.]
Structure Level Pattern Image Note
TS24: epidermis Strong Regionally restricted 2I/J Abundant expression in suprabasal layers of epidermis; no expression in basal cells.
TS24: dermis Absent 2I/J
TS24: hair follicle Absent 2I/J

Specimen 2K,L: embryonic day 16.5 (more )
Note: Enlargement of lower boxed region in 2G.
Structure Level Pattern Image Note
TS24: lip Weak Regionally restricted 2K/L Low expression confined to uppermost layers of the lip epidermis.

Specimen 2M,N: postnatal newborn (more )
Note: Section through dorsal skin.
Structure Level Pattern Image Note
TS27: epidermis Present Regionally restricted 2M/N Expression in the suprabasal epidermis.
TS27: dermis Absent 2M/N No expression in basal cells, dermis, or hair follicles.
TS27: epidermis basal layer Absent 2M/N No expression in basal cells, dermis, or hair follicles.
TS27: hair follicle Absent 2M/N No expression in basal cells, dermis, or hair follicles.

Specimen 3A,B: postnatal adult (more )
Structure Level Pattern Image Note
TS28: stomach proventricular region Strong Regionally restricted 3A/B Strong expression in the stratified squamous epithelium of the forestomach.
TS28: stomach mucosa Weak Regionally restricted 3A/B Low levels of expression in the gastric mucosa and adventitial layers.
TS28: stomach wall Weak Regionally restricted 3A/B Low levels of expression in the gastric mucosa and adventitial layers.

Specimen 3E,F: postnatal adult (more )
Note: Enlargement of boxed region in 3C.
Structure Level Pattern Image Note
TS28: stomach proventricular region Strong Regionally restricted 3E/F Strong expression in the stratified squamous epithelium; sharp discontinuity in expression within a few cells at the squamo-columnar junction between the forestomach and gastric epithelium.
TS28: stomach mucosa Absent 3E/F No expression in the gastric mucosa or lamina propria.
TS28: stomach wall Weak Regionally restricted 3E/F No expression in the gastric mucosa or lamina propria.

Specimen 5E,F: embryonic day 17.5 (more )
Note: Section through a long bone.
Structure Level Pattern Image Note
TS25: cartilage Present Regionally restricted 5E/F Expression only in hypertrophic cartilage; no expression in resting chondrocytes, proliferating chondrocytes or the resting zone.
TS25: limb skeleton Present Regionally restricted 5E/F Expression only in hypertrophic cartilage; no expression in resting chondrocytes, proliferating chondrocytes or the resting zone.

Specimen not shown: embryonic day 6.5 (more )
Structure Level Pattern Image Note
TS9: embryo Present Authors report expression was detectable in 6.5- to 12.5-day p.c. embryos.

Specimen not shown: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: embryo Present Authors report expression was detectable in 6.5- to 12.5-day p.c. embryos.

Specimen not shown: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: cartilage Present Regionally restricted Authors report that expression is specifically localized to cells of hypertrophic cartilage.

Specimen not shown: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: hippocampus Present Regionally restricted Expression in the pyramidal layer of the hippocampus.

Specimen not shown: postnatal newborn (more )
Structure Level Pattern Image Note
TS27: cartilage Present Regionally restricted Authors report that expression is specifically localized to cells of hypertrophic cartilage.
TS27: meninges Present Expression in all three layers of the meninges surrounding the brain and spinal cord.
TS27: central nervous system Weak Low level of expression throughout the neural tissue of newborn brains.

Specimen not shown: postnatal adult (more )
Structure Level Pattern Image Note
TS28: cervix uteri Present
TS28: vagina Present
TS28: endometrium stroma Present Expression in the stromal component of the uterine endometrium.

Specimen not shown: postnatal adult (more )
Structure Level Pattern Image Note
TS28: esophagus Present Regionally restricted
TS28: tongue epithelium Present Regionally restricted Lower levels of expression confined to the uppermost layers of the epithelium in the tongue.
TS28: epidermis Absent No expression adult dorsal epidermis.
TS28: meninges Present Expression in all three layers of the meninges surrounding the brain and spinal cord.
TS28: central nervous system Weak Low level of expression throughout the neural tissue of adult brains.
TS28: hippocampus pyramidal cell layer Strong Higher levels of expression in the pyramidal layer of the hippocampus.


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory