Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Lyz2tm1(HBEGF)Mtka
Name:	lysozyme 2; targeted mutation 1, Masato Tanaka
MGI ID:	MGI:3834185
Synonyms:	LysM-DTR, Lyz2tm1(DTR)Mtka
Gene:	Lyz2  Location: Chr10:117113446-117118177 bp, - strand  Genetic Position: Chr10, 65.34 cM
Alliance:	Lyz2tm1(HBEGF)Mtka page

Germline Transmission:	Earliest citation of germline transmission: J:145285
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Inserted expressed sequence) Mutations:    Insertion, Intragenic deletion   Lyz2tm1(HBEGF)Mtka expresses 1 gene Knock-in expresses: Organism Expressed Gene Homolog in Mouse Note human HBEGF (1839) Hbegf  (MGI:96070)   Mutation details: Exon 1 was replaced with a cDNA for human diphtheria toxin receptor, heparin-binding epidermal growth factor-like growth factor (HB-EGF), and a floxed neo cassette. (J:145285)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Lyz2 Mutation:	41 strains or lines available

Original:	J:145285 Miyake Y, et al., Protective role of macrophages in noninflammatory lung injury caused by selective ablation of alveolar epithelial type II Cells. J Immunol. 2007 Apr 15;178(8):5001-9
All:	3 reference(s)