Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Gli2tm1Blnw
Name:	GLI-Kruppel family member GLI2; targeted mutation 1, Baolin Wang
MGI ID:	MGI:3834146
Synonyms:	GlirP1-4
Gene:	Gli2  Location: Chr1:118761862-118981349 bp, - strand  Genetic Position: Chr1, 52.17 cM, cytoband E2-E4
Alliance:	Gli2tm1Blnw page

Germline Transmission:	Earliest citation of germline transmission: J:145182
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Inserted expressed sequence) Mutations:    Insertion, Intragenic deletion   Mutation details: A floxed neomycin cassette was inserted upstream of the last exon, part of which was replaced with corresponding mouse cDNA sequences containing Ser-Ala mutations in the codons for the first four protein kinase A sites (S789A, S805A, S817A and S848A). The neomycin was left in place because of the increased lethality of heterozygotes that occured when it was removed. (J:145182)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gli2 Mutation:	169 strains or lines available

Original:	J:145182 Pan Y, et al., Phosphorylation of Gli2 by protein kinase A is required for Gli2 processing and degradation and the Sonic Hedgehog-regulated mouse development. Dev Biol. 2009 Feb 1;326(1):177-89
All:	1 reference(s)