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Rad50tm3Jpt
Targeted Allele Detail
Summary
Symbol: Rad50tm3Jpt
Name: RAD50 double strand break repair protein; targeted mutation 3, John H J Petrini
MGI ID: MGI:3832533
Synonyms: Rad50ind
Gene: Rad50  Location: Chr11:53540346-53598146 bp, - strand  Genetic Position: Chr11, 31.98 cM, cytoband A5-B1
Alliance: Rad50tm3Jpt page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:144766
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt1b-m2
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA puromycin resistance cassette with a 5' loxP site was inserted upstream of exon 1, and an additional loxP site was inserted downstream of exon 2. (J:144766)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Rad50 Mutation:  53 strains or lines available
References
Original:  J:144766 Adelman CA, et al., Rad50 is dispensable for the maintenance and viability of postmitotic tissues. Mol Cell Biol. 2009 Jan;29(2):483-92
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory