Tg(KRT14-Artn)1Kma
Transgene Detail
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| Symbol: |
Tg(KRT14-Artn)1Kma |
| Name: |
transgene insertion 1, Kathryn M Albers |
| MGI ID: |
MGI:3829589 |
| Synonyms: |
ART-OE |
| Transgene: |
Tg(KRT14-Artn)1Kma Location: unknown
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| Alliance: |
Tg(KRT14-Artn)1Kma page
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| Transgene Type: |
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Transgenic (Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(KRT14-Artn)1Kma expresses
1 gene
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Mutation details: The transgene consists of a purified fragment containing 2.3 kb of the human K14 keratin promoter sequence, 1.1 kb of mouse artemin DNA, and 1.7 kb of the human growth hormone gene containing intron/exon and poly(A) signal sequences. RT-PCR analysis of transgene expression showed a low level of artemin mRNA in skin from WT mice and an enhanced level in skin of ART-OE mice. At the protein level, comparison of artemin immunolabeling of WT and ART-OE skin showed only slight reactivity in the WT epidermis and a significant enhancement in artemin immunoreactivity in transgenic skin that was restricted to the K14 keratin-expressing keratinocytes.
(J:111687)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:111687 Elitt CM, et al., Artemin overexpression in skin enhances expression of TRPV1 and TRPA1 in cutaneous sensory neurons and leads to behavioral sensitivity to heat and cold. J Neurosci. 2006 Aug 16;26(33):8578-87 |
| All: |
2 reference(s) |
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Analysis Tools
