Summary | Transgene origin | Transgene description | Find Mice (IMSR) | References

Symbol:	Tg(Igk*T)T04Dgs
Name:	transgene insertion T04, David G Schatz
MGI ID:	MGI:3811482
Synonyms:	TgT
Transgene:	Tg(Igk*T)T04Dgs  Location: unknown
Alliance:	Tg(Igk*T)T04Dgs page

Strain of Origin:

C57BL/6 and SJL

Transgene Type:    Transgenic (Inserted expressed sequence) Mutation:    Insertion   Tg(Igk*T)T04Dgs expresses 1 gene Transgene expresses: Organism Expressed Gene Note mouse Igk (MGI:96494)   Mutation details: Vk167/PEPS is a transgene with a truncated region upstream of the promoter. The Igk (immunoglobulin kappa) sequence was further modified in the current strain through the insertion of 5 tandem repeats of a 20-bp adenine/thymine (A/T) fragment near the 3' end of the variable region. The inserted sequence is identical to the insert in the TgA line but is in the reverse orientation. This "TgT" line has an A/T sequence comparable to that found in line "TgC" without the single cytosine:guanine (C:G) insert. (J:139793)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:139793 Unniraman S, et al., Strand-biased spreading of mutations during somatic hypermutation. Science. 2007 Aug 31;317(5842):1227-30
All:	1 reference(s)