Nkx2-2 RNA in situ Gene Expression Assay

Gene Expression Data
Assay Details

Assay

Reference:	J:108509 Blaess S, et al., Sonic hedgehog regulates Gli activator and repressor functions with spatial and temporal precision in the mid/hindbrain region. Development. 2006 May;133(9):1799-809
Assay type:	RNA in situ
MGI Accession ID:	MGI:3810822
Gene symbol:	Nkx2-2
Gene name:	NK2 homeobox 2

Probe:	Nkx2.2 probe4
Probe preparation:	Antisense RNA

Results

2I ©

Specimen 2I: embryonic day 10.5 (more

)
Note: This is a horizontal section.

Structure	Level	Pattern	Image	Note
TS17: midbrain	Present	Regionally restricted	2I	Expression is present in ventral-laterally derived interneurons.
TS17: rhombomere 1	Present	Regionally restricted	2I	Expression is present in ventral-laterally derived interneurons.

2K ©

Specimen 2K: embryonic day 10.5; Smo^tm2Amc/Smo^tm2Amc, En1^tm2(cre)Wrst/En1⁺ (more

)
Note: Conditional mutant. This is a horizontal section.

Structure	Level	Pattern	Image	Note
TS17: midbrain	Absent		2K	There was no expression in the ventral mesencephalon.
TS17: rhombomere 1	Absent		2K

2M ©

Specimen 2M: embryonic day 12.5 (more

)
Note: This is a horizontal section.

Structure	Level	Pattern	Image	Note
TS20: midbrain	Present	Regionally restricted	2M	Expression is present in ventral-laterally derived interneurons.
TS20: cerebellum primordium	Present	Regionally restricted	2M	Expression is present in ventral-laterally derived interneurons.

2O ©

Specimen 2O: embryonic day 12.5; Smo^tm1Amc/Smo^tm2Amc, Tg(Nes-cre)1Kln/0 (more

)
Note: Conditional mutant. This is a horizontal section.

Structure	Level	Pattern	Image	Note
TS20: cerebellum primordium	Present	Regionally restricted	2O	Expression is in ventral neurons, although they were slightly reduced in number compared with wild type.
TS20: midbrain	Present	Regionally restricted	2O	Expression is in ventral neurons, although they were slightly reduced in number compared with wild type.

Specimen Not shown: embryonic day 12.5; Smo^tm2Amc/Smo^tm2Amc, En1^tm2(cre)Wrst/En1⁺ (more

)
Note: Conditional mutant.

Structure	Level	Pattern	Image	Note
TS20: midbrain	Absent			There was no expression in the ventral mesencephalon.
TS20: cerebellum primordium	Absent			There was no expression in rhombomere 1.

Specimen Not shown: embryonic day 18.5; Shh^tm1Chg/Shh^tm1Chg (more

)

Structure	Level	Pattern	Image	Note
TS26: midbrain	Absent			There was no expression in the ventral mesencephalon.
TS26: cerebellum	Absent			There was no expression in rhombomere 1.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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