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Hes1tm1Kag
Targeted Allele Detail
Summary
Symbol: Hes1tm1Kag
Name: hes family bHLH transcription factor 1; targeted mutation 1, Ryoichiro Kageyama
MGI ID: MGI:3808031
Synonyms: Hes1f, Hes1tm1Imayo
Gene: Hes1  Location: Chr16:29883259-29886614 bp, + strand  Genetic Position: Chr16, 21.09 cM
Alliance: Hes1tm1Kag page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:139170
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted after the first coding exon and a floxed neo cassette was inserted after the last coding exon. Expression of cre in ES cells was used to remove the neo cssette leaving coding exons 2 through 4 floxed. (J:139170)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 28 assay results
Tumor Data
List all tumor models in MMHCdb carrying Hes1tm1Kag
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Hes1 Mutation:  21 strains or lines available
References
Original:  J:139170 Imayoshi I, et al., Hes genes and neurogenin regulate non-neural versus neural fate specification in the dorsal telencephalic midline. Development. 2008 Aug;135(15):2531-41
All:  44 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory