Summary | Mutation origin | Mutation description | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Hbatm1(HBA)Tow
Name:	hemoglobin alpha chain complex; targeted mutation 1, Timothy Townes
MGI ID:	MGI:3790755
Synonyms:	HbA, Hbahalpha
Gene:	Hba  Location: unknown  Genetic Position: Chr11, cytoband A

Germline Transmission:	Earliest citation of germline transmission: J:134980
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Humanized sequence, Inserted expressed sequence) Mutations:    Insertion, Intragenic deletion   Hbatm1(HBA)Tow involves 4 genes/genome features (Hba, Hba-x, Hba-a1 ...) View all   Hbatm1(HBA)Tow expresses 3 genes Knock-in expresses: Organism Expressed Gene Homolog in Mouse Note human HBA1 (3039) Hba-a1  (MGI:96015) Hba-a2  (MGI:96016) human HBA2 (3040) Hba-a1  (MGI:96015) Hba-a2  (MGI:96016) human HBZ (3050) Hba-x  (MGI:96019)   Hbatm1(HBA)Tow expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Hba (MGI:96014)     The complex was replaced with human HBA. Details will be described elsewhere. (J:134980)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Hba Mutation:	10 strains or lines available

Original:	J:134980 Wu LC, et al., Correction of sickle cell disease by homologous recombination in embryonic stem cells. Blood. 2006 Aug 15;108(4):1183-8
All:	67 reference(s)