Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	B4galt1tm2Shur
Name:	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1; targeted mutation 2, Barry D Shur
MGI ID:	MGI:3771315
Synonyms:	GalT-null, Long GalT-Null, long gt-
Gene:	B4galt1  Location: Chr4:40804602-40854005 bp, - strand  Genetic Position: Chr4, 20.46 cM
Alliance:	B4galt1tm2Shur page

Germline Transmission:	Earliest citation of germline transmission: J:43773
Parent Cell Line:	AB1 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1+

Allele Type:    Targeted (Modified isoform(s)) Mutations:    Insertion, Nucleotide substitutions   Mutation details: A targeting vector containing neomycin resistance and herpes simplex virus thymidine kinase genes was used to insert a point mutation into the first translation initiation codon in exon 1, which initiates translation of the long isoform. Expression of the long isoform is eliminated. Expression of the short isoform is unaffected. (J:43773)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any B4galt1 Mutation:	41 strains or lines available

Original:	J:43773 Lu Q, et al., Sperm from beta 1,4-galactosyltransferase-null mice are refractory to ZP3-induced acrosome reactions and penetrate the zona pellucida poorly. Development. 1997 Oct;124(20):4121-31
All:	3 reference(s)