Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Chrm3tm2Jwe
Name:	cholinergic receptor, muscarinic 3, cardiac; targeted mutation 2, Jurgen Wess
MGI ID:	MGI:3770175
Synonyms:	Chrm3flox, M3Rfl
Gene:	Chrm3  Location: Chr13:9925522-10410883 bp, - strand  Genetic Position: Chr13, 3.72 cM
Alliance:	Chrm3tm2Jwe page

Germline Transmission:	Earliest citation of germline transmission: J:129643
Parent Cell Line:	TC1/TC-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A floxed neo cassette was inserted downstream of the coding region and an additional loxP site was inserted upstream of the coding region. (J:129643)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Chrm3 Mutation:	50 strains or lines available

Original:	J:129643 Gautam D, et al., A critical role for beta cell M3 muscarinic acetylcholine receptors in regulating insulin release and blood glucose homeostasis in vivo. Cell Metab. 2006 Jun;3(6):449-61
All:	8 reference(s)