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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Chrm3tm2Jwe
targeted mutation 2, Jurgen Wess
MGI:3770175
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Chrm3tm2Jwe/Chrm3tm2Jwe
Tg(Ins2-cre)25Mgn/0 		involves: 129S6/SvEvTac * C57BL/6 * DBA MGI:3770245


Genotype
MGI:3770245
cn1
Allelic
Composition		 Chrm3tm2Jwe/Chrm3tm2Jwe
Tg(Ins2-cre)25Mgn/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chrm3tm2Jwe mutation (0 available); any Chrm3 mutation (50 available)
Tg(Ins2-cre)25Mgn mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased insulin secretion ( J:129643 )
• insulin release following treatment with oxotremorine-M is reduced 50% compared to from wild-type islet cells
• however, total insulin content is normal
impaired glucose tolerance ( J:129643 )
• following administration of glucose, serum glucose levels are increased and insulin levels are decreased compared to in wild-type mice
• however, insulin sensitivity is normal

endocrine/exocrine glands
decreased insulin secretion ( J:129643 )
• insulin release following treatment with oxotremorine-M is reduced 50% compared to from wild-type islet cells
• however, total insulin content is normal




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory