Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Dlg5tm1Vv
Name:	discs large MAGUK scaffold protein 5; targeted mutation 1, Valeri Vasioukhin
MGI ID:	MGI:3757646
Gene:	Dlg5  Location: Chr14:24184021-24295988 bp, - strand  Genetic Position: Chr14, 14.26 cM
Alliance:	Dlg5tm1Vv page

Germline Transmission:	Earliest citation of germline transmission: J:124940
Parent Cell Line:	GS1 (ES Cell)
Strain of Origin:	129/Sv

Allele Type:    Targeted (Null/knockout, Reporter) Mutation:    Insertion   Mutation details: Exon 2 was disrupted with an IRES-beta-geo cassette, creating a stop codon 25 amino acids after the translation initiation site. Northen and Western blot analysis on brains from homozygotes demonstrated complete absence of gene expression. (J:124940)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	113 assay results
In Structures Affected by this Mutation:	11 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dlg5 Mutation:	126 strains or lines available

Original:	J:124940 Nechiporuk T, et al., Failure of epithelial tube maintenance causes hydrocephalus and renal cysts in dlg5(-/-) mice. Dev Cell. 2007 Sep;13(3):338-50
All:	5 reference(s)