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Trpm8tm1Jul
Targeted Allele Detail
Summary
Symbol: Trpm8tm1Jul
Name: transient receptor potential cation channel, subfamily M, member 8; targeted mutation 1, David Julius
MGI ID: MGI:3716518
Synonyms: Trpm8-, trpm8-(DJ)
Gene: Trpm8  Location: Chr1:88234457-88318909 bp, + strand  Genetic Position: Chr1, 44.57 cM
Alliance: Trpm8tm1Jul page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:122978
Parent Cell Line:  E14TG2a.4 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe self excising ACN cassette was inserted to replace exons 13 and 14. Amino acids 594-661, located in the presumptive cytoplasmic amino-terminal domain, were deleted from the locus, introducing a premature stop codon before and a frame shift after the deleted region. RT-PCR confirmed absence of transcript from mutant trigeminal ganglia. (J:122978)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Trpm8 Mutation:  61 strains or lines available
References
Original:  J:122978 Bautista DM, et al., The menthol receptor TRPM8 is the principal detector of environmental cold. Nature. 2007 Jul 12;448(7150):204-8
All:  34 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory