Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol: Rad51ctm1Sks Name: RAD51 paralog C; targeted mutation 1, Shyam K Sharan MGI ID: MGI:3707422 Synonyms: Rad51cneo Gene: Rad51c  Location: Chr11:87267471-87295780 bp, - strand  Genetic Position: Chr11, 52.08 cM Alliance: Rad51ctm1Sks page

Testes abnormalities in Rad51ctm1Sks/Rad51ctm1.1Sks mice Show the 2 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:119835
Parent Cell Line:	CJ7 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ Kitl+

Allele Type:    Targeted (Conditional ready, Hypomorph) Mutation:    Insertion   Mutation details: A floxed neo cassette is inserted between exon 1 and 2 with the addition of a loxP site 3' of exon 3 creating a hypomorphic allele. Aberrant splicing products were confirmed by RT-PCR and decreased protein production was confirmed by quantification of a western blots on mice testicular tissue. (J:119835)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	8 anatomical structure(s)

List all tumor models in MMHCdb carrying Rad51ctm1Sks

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Rad51c Mutation:	24 strains or lines available

Original:	J:119835 Kuznetsov S, et al., RAD51C deficiency in mice results in early prophase I arrest in males and sister chromatid separation at metaphase II in females. J Cell Biol. 2007 Feb 26;176(5):581-92
All:	4 reference(s)