Summary | Transgene origin | Transgene description | Recombinase activity | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tg(Lck-cre)I540Jxm
Name:	transgene insertion I540, Jamey Marth
MGI ID:	MGI:3701502
Transgene:	Tg(Lck-cre)I540Jxm  Location: unknown
Alliance:	Tg(Lck-cre)I540Jxm page

Strain of Origin:

(C57BL/6 x CBA)F2

Transgene Type:    Transgenic (Recombinase) Mutation:    Insertion   Tg(Lck-cre)I540Jxm expression driven by 1 gene Transgene expression driven by: Organism Driver Gene Note mouse Lck (MGI:96756)   Mutation details: The Cre recombinase coding sequence, modified by addition of a Kozak consensus translation start sequence and nuclear localization signals, was inserted into the p1017 expression vector between the thymocyte-specific, mouse proximal Lck promoter and most of the human growth hormone gene, extending from within exon 1 through the polyadenylation signal. Cre recombinase activity is restricted to thymocytes; evidence of activity in spleen is attributed to the presence of thymus-derived T lymphocytes. (J:67674, J:81268)

Activity:	Tissue activity of this recombinase allele
Driver:	Lck (mouse) Summary of all recombinase alleles driven by Lck. Alliance mouse Lck gene page

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:67674 Hennet T, et al., T-cell-specific deletion of a polypeptide N-acetylgalactosaminyl-transferase gene by site-directed recombination. Proc Natl Acad Sci U S A. 1995 Dec 19;92(26):12070-4
All:	18 reference(s)