Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Furintm1Jwmc
Name:	furin, paired basic amino acid cleaving enzyme; targeted mutation 1, John W M Creemers
MGI ID:	MGI:3700008
Synonyms:	furfl, Furflox, Furinflox
Gene:	Furin  Location: Chr7:80038942-80055188 bp, - strand  Genetic Position: Chr7, 45.65 cM, cytoband D1-E2
Alliance:	Furintm1Jwmc page

Germline Transmission:	Earliest citation of germline transmission: J:118515
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A targeting vector was designed to flank exon 2 with loxP sites. A floxed neo included in the vector was subsequently removed via transient cre expression. (J:118515)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	6 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Furin Mutation:	45 strains or lines available

Original:	J:118515 Roebroek AJ, et al., Limited redundancy of the proprotein convertase furin in mouse liver. J Biol Chem. 2004 Dec 17;279(51):53442-50
All:	19 reference(s)