Summary | Transgene origin | Transgene description | Expression | Recombinase activity | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Tg(CDX2-cre)101Erf
Name:	transgene insertion 101, Eric R Fearon
MGI ID:	MGI:3696953
Synonyms:	CDX2P 9.5-NLS Cre, CDX2P9.5-NLSCre, CDX2P-NLS Cre, CPC, Tg(CDX2-cre)1Erf
Transgene:	Tg(CDX2-cre)101Erf  Location: unknown
Alliance:	Tg(CDX2-cre)101Erf page

Strain of Origin:

(C57BL/6J x SJL/J)

Transgene Type:    Transgenic (Recombinase) Mutation:    Insertion   Tg(CDX2-cre)101Erf expression driven by 1 gene Transgene expression driven by: Organism Driver Gene Homolog in Mouse Note human CDX2 (1045) Cdx2  (MGI:88361)   Mutation details: The CDX2P9.5-NLSCre transgene was designed with a 9.5 kb promoter fragment from the 5' flanking sequences of human caudal type homeo box 2 (CDX2) gene, a Cre recombinase gene with nuclear localization signal, and a bovine growth hormone polyadenylation cassette. This transgene was injected into (C57BL/6J x SJL/J) hybrid cells. Transgenic founders (line 101) were found to have approximately 50 copies of the transgene and were bred to C57BL/6J mice. Cre expression is noted in epithelium of the ileum and cecum and throughout the colon. During early development, expression is observed throughout the caudal region of the embryo. (J:126018)

Activity:	Tissue activity of this recombinase allele
Driver:	CDX2 (human) Summary of all recombinase alleles driven by CDX2. Comparative matrix view of recombinase activities Alliance human CDX2 gene page

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

3 assay results 1 RNA-Seq or microarray experiment(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:117412 Feng Y, et al., Drosophila split ends homologue SHARP functions as a positive regulator of Wnt/beta-catenin/T-cell factor signaling in neoplastic transformation. Cancer Res. 2007 Jan 15;67(2):482-91
All:	37 reference(s)