Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mstntm3.1Sjl mutation
(0 available);
any
Mstn mutation
(33 available)
Tg(CDX2-cre)101Erf mutation
(1 available)
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homeostasis/metabolism
muscle
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• two posteriorly located muscles, quadriceps and gastrocnemius, have dramatically higher weights than those of control mice at 10 weeks of age, while the anteriorly located muscles, pectoralis and triceps, have a slight increase, likely due to the decreased levels of serum myostatin. The increase in quadriceps size in both males and females is statistically larger in mice homozygous for a null allele than in these compartmentally null mice indicating that serum myostatin generated from anterior muscles has an impact, albeit a minority impact, on posterior muscles
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• the gastrocnemius, assessed from females, has an increase in the total number of muscle fibers from an average of 8,802 in the absence of cre to 13,079 in the presence of cre
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• the gastrocnemius, assessed from females, has an increase in the fiber diameter of muscle fibers averaging 16.5% larger than the muscle fibers in the absence of cre
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apctm1Tno mutation
(6 available);
any
Apc mutation
(154 available)
Il23atm1Ngh mutation
(0 available);
any
Il23a mutation
(25 available)
Tg(CDX2-cre)101Erf mutation
(1 available)
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neoplasm
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• reduced colorectal tumor multiplicity and grown due to reduced cell proliferation compared with Apctm1Tno/Apc+ Tg(CDX2-cre)101Erf mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apctm1Tno mutation
(6 available);
any
Apc mutation
(154 available)
Il17ratm1Koll mutation
(0 available);
any
Il17ra mutation
(46 available)
Tg(CDX2-cre)101Erf mutation
(1 available)
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neoplasm
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• reduced colorectal tumor multiplicity and grown compared to in Apctm1Tno/Apc+ Tg(CDX2-cre)101Erf mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Neurog3tm3.1Ggr mutation
(0 available);
any
Neurog3 mutation
(18 available)
Tg(CDX2-cre)101Erf mutation
(1 available)
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digestive/alimentary system
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• normal sensitivity to DSS-induced colitis
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apctm1Tno mutation
(6 available);
any
Apc mutation
(154 available)
Il23rtm1.2Trin mutation
(0 available);
any
Il23r mutation
(68 available)
Tg(CDX2-cre)101Erf mutation
(1 available)
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neoplasm
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• reduced colorectal tumor multiplicity and grown compared to in Apctm1Tno/Apc+ Tg(CDX2-cre)101Erf mice
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mortality/aging
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• 36% (13/36) animals survived to 300 days of observation; 3 died and 20 were euthanized upon signs of distress
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growth/size/body
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• males show inhibited weight gain after 120 days
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neoplasm
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• mice show around 10 tumors
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• an average of 5-8 tumors are found in colon and rectum, wit some tumors being observed in the cecum and distal small intestine
• colorectal tumors may be observed at early time points
• male mice have about 60% more colon tumors than controls
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• a small number of mice also develop mammary tumors
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digestive/alimentary system
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• greater than half the animals observed developed rectal prolapse with intermittent bleeding
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• an average of 5-8 tumors are found in colon and rectum, wit some tumors being observed in the cecum and distal small intestine
• colorectal tumors may be observed at early time points
• male mice have about 60% more colon tumors than controls
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• some (3) animals died during the observation period from intestinal obstruction by tumor
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hematopoietic system
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• mice exhibit mild anemia
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• mice displaying mild anemia show hematocrits in range of 33 to 35% compared to around 45% in controls
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endocrine/exocrine glands
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• a small number of mice also develop mammary tumors
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integument
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• a small number of mice also develop mammary tumors
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mortality/aging
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• embryonic lethality is observed
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psmf1tm1c(EUCOMM)Hmgu mutation
(0 available);
any
Psmf1 mutation
(11 available)
Tg(CDX2-cre)101Erf mutation
(1 available)
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mortality/aging
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• all mice die by 3 to 4 weeks of age
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behavior/neurological
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• mice begin to develop progressive neuromotor phenotypes around P6, characterized by spasticity, rigid muscle tone, strong tremor, and severely impaired righting response
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• severely impaired righting response
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• mice exhibit hindlimb clasping between episodes of tremor when picked up by tails
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• mice are only able to move using their front legs since their hind limbs are hyperextended and paralyzed
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muscle
Analysis Tools