Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Cdc42tm1Yizh
Name:	cell division cycle 42; targeted mutation 1, Yi Zheng
MGI ID:	MGI:3693320
Synonyms:	cdc42flox, Cdc42loxP
Gene:	Cdc42  Location: Chr4:137047007-137085031 bp, - strand  Genetic Position: Chr4, 69.83 cM
Alliance:	Cdc42tm1Yizh page

Germline Transmission:	Earliest citation of germline transmission: J:116100
Parent Cell Line:	iTL1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: The targeting construct introduced a neomycin resistance cassette (neor), flanked on each side by a loxP followed by a frt site, upstream of exon 2 and a single loxP site downstream of exon 2. The neor was deleted by FLP recombinase, leaving a single frt site in intron 1 and loxP sites flanking exon 2, which contains the translation initiation site. (J:120090)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	32 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cdc42 Mutation:	43 strains or lines available

Original:	J:116100 Chen L, et al., Cdc42 deficiency causes Sonic hedgehog-independent holoprosencephaly. Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16520-5
All:	44 reference(s)