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plt Gene Detail
Summary
  • Symbol
    plt
  • Name
    paucity of lymph node T cells
  • Feature Type
    heritable phenotypic marker
  • IDs
    MGI:3664332
  • Alliance
Location &
Maps
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  • Sequence Map
    Genome coordinates not available from the current reference assembly.
  • Genetic Map
    Chromosome 4, Syntenic
Human Diseases
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  • Diseases
    1 with plt mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    30 phenotypes from 1 allele in 4 genetic backgrounds
    79 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
In homozygous mutant mice, naive T cells fail to localize in the lymph nodes or in the lymphoid regions of the spleen.
References
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  • Summaries
    All 80
    Diseases 1
    Phenotypes 79
  • Earliest
    J:15290 Nakano H, et al., Nonspecific augmentation of lymph node T cells and I-E-independent selective deletion of V beta 14+ T cells by Mtv-2 in the DDD mouse. Eur J Immunol. 1993 Oct;23(10):2434-9
  • Latest
    J:324366 Honjoh K, et al., Relationship of Inflammatory Cytokines From M1-Type Microglia/Macrophages at the Injured Site and Lumbar Enlargement With Neuropathic Pain After Spinal Cord Injury in the CCL21 Knockout (plt) Mouse. Front Cell Neurosci. 2019;13:525

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory