Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Myh6tm1Rbns Name: myosin, heavy polypeptide 6, cardiac muscle, alpha; targeted mutation 1, Jeffrey Robbins MGI ID: MGI:3652543 Synonyms: alpha-MyHC- Gene: Myh6  Location: Chr14:55179378-55204384 bp, - strand  Genetic Position: Chr14, 28.01 cM Alliance: Myh6tm1Rbns page

Fibrotic lesions in Myh6tm1Rbns/Myh6+ hearts Show the 4 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:36089
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A PGK-neo-pA cassette replaced the 5' UTR, the start sites of transcription and translation and the first 3 exons of the locus. (J:36089)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Myh6 Mutation:	206 strains or lines available

Original:	J:36089 Jones WK, et al., Ablation of the murine alpha myosin heavy chain gene leads to dosage effects and functional deficits in the heart. J Clin Invest. 1996 Oct 15;98(8):1906-17
All:	3 reference(s)