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| Caption | Histopathology of mouse hearts. Hearts were fixed and mounted in paraffin blocks apex down. Adjacent step serial sections (5um) were taken every 75um. Representative transverse sections of hearts from Myh6tm1Rbns/Myh6+ mice stained with hematoxylin and eosin (C and E) or trichrome (D and F) are shown. These sections were matched to wild type sections shown in panels A and B with regard to the position within the heart. The focal fibrotic lesions shown are characteristic of lesions seen in 5/8 heterozygous mouse hearts examined (arrows, D and F). No such lesions were seen in the ventricles of wild type mice (B). (A) shows a wild type section stained with hematoxylin and eosin. Although the hearts were fixed under identical conditions and were not significantly different in overall weight or measure, several heterozygous hearts showed a definite thickening of the left ventricular wall and septum. In a few cases, this extended to the right ventricular wall. lv, left ventricle; rv, right ventricle. x14. | ||||
| Copyright | This image is from Jones WK, J Clin Invest 1996 Oct 15;98(8):1906-17 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:36089 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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