Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Gria2tm2Rlh
Name:	glutamate receptor, ionotropic, AMPA2 (alpha 2); targeted mutation 2, Richard L Huganir
MGI ID:	MGI:3623451
Synonyms:	GluR2 K882A
Gene:	Gria2  Location: Chr3:80588757-80710142 bp, - strand  Genetic Position: Chr3, 35.5 cM
Alliance:	Gria2tm2Rlh page

Germline Transmission:	Earliest citation of germline transmission: J:107573
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Not Specified) Mutations:    Insertion, Nucleotide substitutions   Mutation details: A targeting vector was designed to insert a floxed neo into the locus as well as the K882A substitution into the exon encoding transmembrane domain 4 and the C terminus region. The neo was subsequently removed via cre recombinase expression. A reduction in the levels of the long isoform was found particularly in mutants of 1 month of age. (J:107573)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gria2 Mutation:	75 strains or lines available

Original:	J:107573 Steinberg JP, et al., Targeted in vivo mutations of the AMPA receptor subunit GluR2 and its interacting protein PICK1 eliminate cerebellar long-term depression. Neuron. 2006 Mar 16;49(6):845-60
All:	5 reference(s)