Tg(Pim1-Frat1)5Brn
Transgene Detail
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| Symbol: |
Tg(Pim1-Frat1)5Brn |
| Name: |
transgene insertion 5, Anton Berns |
| MGI ID: |
MGI:2388580 |
| Synonyms: |
EppF5 |
| Transgene: |
Tg(Pim1-Frat1)5Brn Location: unknown
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| Alliance: |
Tg(Pim1-Frat1)5Brn page
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| Transgene Type: |
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Transgenic (Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(Pim1-Frat1)5Brn expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Note |
| mouse |
Frat1 (MGI:109450) |
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Mutation details: A 920 bp fragment encompassing the Frat1 coding region was adjoined to the Pim1 promoter region and 2 immunoglobulin heavy chain enhancers (E-mu). The Frat1 coding region was followed by a Moloney murine leukemia virus (MoMuLV) long terminal repeat. Northern blot analysis detected expression of the the transgene in all tissues tested. This founder line harbored 2 to 3 copies of the transgenic construct.
(J:59555)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:59555 Jonkers J, et al., Overexpression of Frat1 in transgenic mice leads to glomerulosclerosis and nephrotic syndrome, and provides direct evidence for the involvement of Frat1 in lymphoma progression. Oncogene. 1999 Oct 28;18(44):5982-90 |
| All: |
2 reference(s) |
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Analysis Tools
