Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Rr27tm4Msb
Name:	regulatory region 27; targeted mutation 4, Marisa S Bartolomei
MGI ID:	MGI:3617971
Synonyms:	H19delta3.8kb-5'H19, H19tm5Msb
Gene:	Rr27  Location: unknown  Genetic Position: Chr7, Syntenic
Alliance:	Rr27tm4Msb page

Germline Transmission:	Earliest citation of germline transmission: J:106218
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Modified regulatory region, Null/knockout) Mutation:    Intragenic deletion   Mutation details: The targeting vector replaced 3.8 kb of sequence including the entire DMD and G-rich repeat element. Cre-mediated recombination removed the floxed neomycin resistance gene cassette. (J:106218)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Rr27 Mutation:	6 strains or lines available

Original:	J:106218 Thorvaldsen JL, et al., Analysis of sequence upstream of the endogenous H19 gene reveals elements both essential and dispensable for imprinting. Mol Cell Biol. 2002 Apr;22(8):2450-62
All:	5 reference(s)