Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Spink1tm1Kymm
Name:	serine peptidase inhibitor, Kazal type 1; targeted mutation 1, Ken-ichi Yamamura
MGI ID:	MGI:3613294
Synonyms:	Spink3-
Gene:	Spink1  Location: Chr18:43861134-43870302 bp, - strand  Genetic Position: Chr18, 23.47 cM, cytoband B3
Alliance:	Spink1tm1Kymm page

Germline Transmission:	Earliest citation of germline transmission: J:104647
Parent Cell Line:	TT2 (ES Cell)
Strain of Origin:	(C57BL/6NCrlj x CBA/JNCrlj)F1

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: A PGK-neo flanked by the mutated loxP sites lox71 and lox2272 was inserted immediately upstream of the ATG in exon 1. Northern blot failed to detect transcript and Western blot failed to detect protein in mutants. (J:104647)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	7 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Spink1 Mutation:	13 strains or lines available

Original:	J:104647 Ohmuraya M, et al., Autophagic cell death of pancreatic acinar cells in serine protease inhibitor Kazal type 3-deficient mice. Gastroenterology. 2005 Aug;129(2):696-705
All:	2 reference(s)