Analysis Tools
mortality/aging
|
• 50% die by 3.5 days after birth and all die by 14.5 days after birth
|
growth/size/body
|
• do not gain weight after birth
|
endocrine/exocrine glands
|
• progressive atrophy of pancreas after birth
• At 3.5 days after birth, the pancreatic bed is small and transparent
• at 7.5 days after birth, rapid loss of acinar cells results in lobular contraction and leads to tightly clustered tubular complexes associated with small numbers of residual acinar cells, however inflammatory cell infiltration is scarce
|
|
• progressive degeneration of acinar cells caused by autophagic cell death and not necrosis or apoptosis
• vacuolization of acinar cells is first observed at E16.5 with degeneration becoming evident at 0.5 days after birth and severe at 3.5 days after birth
|
|
• no evidence of regeneration of acini
|
digestive/alimentary system
|
• progressive degeneration of acinar cells caused by autophagic cell death and not necrosis or apoptosis
• vacuolization of acinar cells is first observed at E16.5 with degeneration becoming evident at 0.5 days after birth and severe at 3.5 days after birth
|
|
• at 3.5 days after birth, but not at P1.5, the small intestine is expanded, with the thin smooth muscle layer and villi mostly degenerated
|
|
• at 3.5 days after birth, but not at P1.5, the duodenum is expanded, with the thin smooth muscle layer and villi mostly degenerated
|
hematopoietic system
small spleen
(
J:104647
)
|
• spleen is smaller after birth, although histologically, the structure is normal
|
homeostasis/metabolism
dehydration
(
J:104647
)
immune system
small spleen
(
J:104647
)
|
• spleen is smaller after birth, although histologically, the structure is normal
|
integument
sparse hair
(
J:104647
)
|
• have very little fur
|
