Summary | Mutation origin | Mutation description | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Cdkn1btm2Jro
Name:	cyclin dependent kinase inhibitor 1B; targeted mutation 2, James M Roberts
MGI ID:	MGI:3611831
Synonyms:	P27S10A
Gene:	Cdkn1b  Location: Chr6:134897364-134902476 bp, + strand  Genetic Position: Chr6, 65.77 cM
Alliance:	Cdkn1btm2Jro page

Germline Transmission:	Earliest citation of germline transmission: J:103819
Parent Cell Line:	AK7.1 (ES Cell)
Strain of Origin:	129S4/SvJaeSor

Allele Type:    Targeted Mutation:    Insertion   Mutation details: The main phosphorylation site was changed from serine to alanine at amino acid position 10 by homologous recombination. (J:103819)

View phenotypes and curated references for all genotypes (concatenated display).

List all tumor models in MMHCdb carrying Cdkn1btm2Jro

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cdkn1b Mutation:	25 strains or lines available

Original:	J:103819 Besson A, et al., A pathway in quiescent cells that controls p27Kip1 stability, subcellular localization, and tumor suppression. Genes Dev. 2006 Jan 1;20(1):47-64
All:	5 reference(s)