Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ccl24tm1Mer
Name:	C-C motif chemokine ligand 24; targeted mutation 1, Marc E Rothenberg
MGI ID:	MGI:3606463
Synonyms:	eotaxin-2
Gene:	Ccl24  Location: Chr5:135598791-135601903 bp, - strand  Genetic Position: Chr5, 75.28 cM, cytoband G1
Alliance:	Ccl24tm1Mer page

Germline Transmission:	Earliest citation of germline transmission: J:98708
Parent Cell Line:	KG-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance cassette replaces 1.86 kb of DNA containing all of exon 1 through exon 2 of the gene. Northern blot analysis of nine tissues demonstrated no detectable mRNA expression in homozygous mutants. ELISA detected no protein in bronchoalveolar lavage fluid of mutant mice. (J:98708, J:102034)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ccl24 Mutation:	7 strains or lines available

Original:	J:98708 Pope SM, et al., Identification of a cooperative mechanism involving interleukin-13 and eotaxin-2 in experimental allergic lung inflammation. J Biol Chem. 2005 Apr 8;280(14):13952-61
All:	8 reference(s)