Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccl24tm1Mer mutation
(0 available);
any
Ccl24 mutation
(7 available)
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immune system
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• Background Sensitivity: interleukin-13-induced eosinophil migration to the lung raised eosinophil numbers in bronchoalveolar lavage fluid 9-fold less in mutant than in wildtype mice
(J:98708)
• Upon a second intranasal ovalbumin challenge after initial intraperitoneal sensitization, mutant mice exhibit a 4-fold greater elevation in peripheral blood eosinophil counts than do similarly challenged wild-type controls
(J:102034)
• Upon a second intranasal ovalbumin challenge after initial intraperitoneal sensitization, mutant mice have 4-fold fewer eosinophils in bronchoalveolar lavage fluid (BALF) than do similarly challenged wild-type controls
(J:102034)
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccl24tm1Mer mutation
(0 available);
any
Ccl24 mutation
(7 available)
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immune system
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• Background Sensitivity: interleukin-13-induced eosinophil migration to the lung raised their numbers in bronchoalveolar lavage fluid 50-fold less in mutant than in wildtype mice - background dependent
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccl11tm1Mer mutation
(3 available);
any
Ccl11 mutation
(15 available)
Ccl24tm1Mer mutation
(0 available);
any
Ccl24 mutation
(7 available)
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immune system
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• doubly mutant mice have 1.5-2-fold as many eosinophils in the bone marrow and peripheral blood as do wild-type 129S/SvEv mice
• doubly mutant mice have 85-fold fewer eosinophils in the jejunum than do wild-type 129S/SvEv mice
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• upon a second intranasal ovalbumin challenge after initial intraperitoneal sensitization, doubly mutant mice exhibit a 10-fold greater elevation in peripheral blood eosinophil counts than do similarly challenged wild-type controls
• upon a second intranasal ovalbumin challenge after initial intraperitoneal sensitization, doubly mutant mice have 7-fold fewer eosinophils in bronchoalveolar lavage fluid (BALF) than do similarly challenged wild-type controls and significantly fewer than mice mutant only for Ccl24 (p<0.01) or Ccl11 (p<0.05); numbers of BALF noneosinophils do not differ between mutant and wild-type mice
• upon a second intranasal ovalbumin challenge after initial intraperitoneal sensitization, doubly mutant mice have 85% fewer peribronchial eosinophils than wild-type or singly mutant mice; the double mutants have eosinophils scattered in the lung parenchyma, rather than concentrated in peribronchial and perivascular inflammatory infiltrates as in wild-type and singly mutant mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccl11tm1Mer mutation
(3 available);
any
Ccl11 mutation
(15 available)
Ccl24tm1Mer mutation
(0 available);
any
Ccl24 mutation
(7 available)
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hematopoietic system
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N |
• lymphocyte and macrophage accumulation in bronchoalveolar fluid is unaffected
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• eosinophils are absent in bronchoalveolar lavage fluid after Aspergillus fumigatus exposure
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immune system
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• eosinophils are absent in bronchoalveolar lavage fluid after Aspergillus fumigatus exposure
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respiratory system
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• reduced mucus production after Aspergillus fumigatus exposure
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Analysis Tools