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Gene Expression Data
Assay Details
Assay
Reference: J:97538 Pelka GJ, et al., Distinct expression profiles of Mecp2 transcripts with different lengths of 3'UTR in the brain and visceral organs during mouse development. Genomics. 2005 Apr;85(4):441-52
Assay type: RNA in situ
MGI Accession ID: MGI:3590653
Gene symbol: Mecp2
Gene name: methyl CpG binding protein 2
Probe: pGP14all
Probe preparation: Antisense labelled with digoxigenin RNA
Visualized with: Alkaline phosphatase
Assay notes: All time points were assayed using both probes, pGP1710 (MGI:3590558) and pGP14all (MGI:3590555); both probes showed similar results. Only results shown in Figures or included in Table 1 are shown below.
Results
Specimen 1B: embryonic day 6.25 (more )
Structure Level Pattern Image Note
TS9: embryo Present 1B Expression detected in the epiblast and extraembryonic ectoderm.
TS9: extraembryonic ectoderm Present 1B Expression detected in the epiblast and extraembryonic ectoderm.
TS9: extraembryonic visceral endoderm Absent 1B
Specimen 1C: embryonic day 6.25 (more )
Structure Level Pattern Image Note
TS9: embryo Present 1C Expression detected in the epiblast and extraembryonic ectoderm.
TS9: extraembryonic ectoderm Present 1C Expression detected in the epiblast and extraembryonic ectoderm.
TS9: extraembryonic visceral endoderm Absent 1C
Specimen 1E: embryonic day 8.5 (more )
Structure Level Pattern Image Note
TS13: neural tube Strong 1E
TS13: paraxial mesenchyme Strong Non-Uniform 1E Strong expression detected in the paraxial mesenchyme with moderate expression in other somitic tissue.
TS13: somite Moderate 1E
Specimen 1F: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS18: neural tube Strong 1F
TS18: trunk paraxial mesenchyme Strong 1F
TS18: embryo Present Regionally restricted 1F Expression was strong in the neural tube and paraxial mesoderm and moderate in other somatic tissues.
Specimen 1G: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: central nervous system Present 1G Wide expression is detected in the CNS.
TS20: brain ventricular layer Strong 1G
TS20: forebrain Strong 1G
TS20: midbrain Strong 1G
TS20: pons Strong 1G
TS20: spinal cord Strong 1G
TS20: spinal cord ventricular layer Strong 1G
Specimen 1I: embryonic day 12.5 (more )
Note: Specimen is a coronal section of the diencephalon.
Structure Level Pattern Image Note
TS20: brain ventricular layer Strong 1I
TS20: trigeminal ganglion Strong 1I
Specimen 1J: embryonic day 14.5 (more )
Note: Specimen is a coronal section of the diencephalon.
Structure Level Pattern Image Note
TS22: central nervous system Present 1J Wide expression is detected in the CNS.
TS22: brain ventricular layer Strong 1J
TS22: cerebral cortex Strong 1J
TS22: corpus striatum Strong 1J
TS22: forebrain Strong 1J
TS22: midbrain Strong 1J
TS22: pons Strong 1J
TS22: spinal cord Strong 1J
TS22: spinal cord ventricular layer Strong 1J
TS22: thalamus Strong Regionally restricted 1J Strong expression is detected in the dorsal thalamus.
TS22: forelimb digit Present 1J
TS22: hindlimb digit Present 1J
TS22: oral epithelium Present 1J
Specimen 1K: embryonic day 14.5 (more )
Note: Specimen is a coronal section of the spinal cord.
Structure Level Pattern Image Note
TS22: spinal cord Strong 1K
TS22: spinal ganglion Strong 1K
Specimen 1L: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: brain ventricular layer Strong 1L
TS22: basisphenoid cartilage condensation Present 1L
TS22: oral cavity Present 1L
TS22: oral epithelium Present 1L
TS22: tongue Present 1L
Specimen 1M: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: central nervous system Present 1M Wide expression is detected in the CNS.
TS24: brain ventricular layer Strong 1M
TS24: cerebral cortex Strong 1M
TS24: corpus striatum Strong 1M
TS24: forebrain Strong 1M
TS24: midbrain Strong 1M
TS24: pons Strong 1M
TS24: spinal cord Strong 1M
TS24: spinal cord ventricular layer Strong 1M
TS24: thalamus Strong Regionally restricted 1M Expression detected in the dorsal thalamus.
TS24: oral epithelium Present 1M
Specimen 1N: postnatal day 2 (more )
Structure Level Pattern Image Note
TS27: cerebellum granule cell layer Present Regionally restricted 1N Expression detected in the external granular cell layer of cerebellum.
TS27: medulla oblongata Weak 1N
TS27: pons Weak 1N
Specimen 1O: postnatal week 2 (more )
Structure Level Pattern Image Note
TS28: cerebellum Strong 1O
TS28: main olfactory bulb granule cell layer Strong 1O
TS28: thalamus Strong 1O
Specimen 1P: postnatal week 10 (more )
Structure Level Pattern Image Note
TS28: cerebellum Strong 1P
TS28: forebrain Strong 1P
TS28: main olfactory bulb Strong 1P
TS28: midbrain Strong 1P
Specimen 1Q: postnatal week 20 (more )
Structure Level Pattern Image Note
TS28: caudate-putamen Present 1Q
TS28: cortical layer II Present 1Q
TS28: cortical layer III Present 1Q
TS28: hippocampal formation Present 1Q
TS28: main olfactory bulb granule cell layer Present 1Q
Specimen 1U: postnatal week 20 (more )
Structure Level Pattern Image Note
TS28: amygdala Present 1U
TS28: hippocampal formation Present 1U
TS28: hypothalamus Present 1U
TS28: piriform cortex Present 1U
Specimen not shown: embryonic day 6.0 (more )
Structure Level Pattern Image Note
TS8: epiblast Strong
TS8: extraembryonic ectoderm Weak
Specimen not shown: embryonic day 9.25 (more )
Structure Level Pattern Image Note
TS15: neural tube Strong
TS15: trunk somite Moderate
TS15: trunk paraxial mesenchyme Strong Non-Uniform Strong expression detected in the paraxial mesenchyme with moderate expression in other somitic tissue.
Specimen not shown: postnatal week 20 (more )
Structure Level Pattern Image Note
TS28: hippocampus stratum oriens Weak
TS28: hippocampus stratum radiatum Weak
TS28: corpus callosum Absent
Specimen 2A: postnatal day 2 (more )
Structure Level Pattern Image Note
TS27: caudate-putamen Present 2A
TS27: cerebral cortex Present 2A
TS27: hippocampus Present 2A
TS27: main olfactory bulb Present 2A
TS27: mammillary body Present 2A
TS27: pontine nucleus Present 2A
TS27: thalamus Present 2A
Specimen 2B: postnatal day 2 (more )
Note: Pane B is a high magnification of a region of A.
Structure Level Pattern Image Note
TS27: cingulate cortex Present 2B
Specimen 2C: postnatal day 2 (more )
Note: Pane C is a high magnification of a region of A.
Structure Level Pattern Image Note
TS27: lateral habenular nucleus Present 2C Expression detected in lateral habenular nucleus and medidorsal thalamic nucleus.
TS27: medial thalamic group Present 2C Expression detected in lateral habenular nucleus and medidorsal thalamic nucleus.
Specimen 2D: postnatal day 2 (more )
Note: Pane D is a high magnification of a region of A.
Structure Level Pattern Image Note
TS27: hippocampus CA1 Present Regionally restricted 2D Expression detected in the pyramidal cells of the CA1 region of the hippocampus.
Specimen 2E: postnatal day 2 (more )
Note: Pane E is a high magnification of a region of A.
Structure Level Pattern Image Note
TS27: hypothalamus medial zone tuberal area Present Regionally restricted 2E Expression was detected in cells in the vicinity of the tuber cinereum.
Specimen 2F, G: postnatal week 6 (more )
Note: Pane G is a high magnification of a region of F.
Structure Level Pattern Image Note
TS28: caudate-putamen Present 2F , 2G
TS28: hippocampus pyramidal cell layer Present 2F , 2G
TS28: main olfactory bulb Present 2F , 2G
TS28: neocortex layer Present Regionally restricted 2F , 2G Expression was detected in the superficial cell layers of the cortex.
TS28: dentate gyrus Weak Regionally restricted 2F , 2G Weak expression was detected adjacent to the dentate gyrus.
Specimen 2H: postnatal week 11 (more )
Structure Level Pattern Image Note
TS28: neocortex layer Present Regionally restricted 2H Expression was detected in the superficial cell layers of the cortex.
TS28: hypothalamus Present 2H
TS28: mammillary body Present 2H
TS28: pontine nucleus Present 2H
Specimen not shown: postnatal week 11 (more )
Structure Level Pattern Image Note
TS28: inferior colliculus Present
TS28: superior colliculus Present
TS28: main olfactory bulb Present Regionally restricted Expression detected in the accessory olfactory bulb.
TS28: retina outer plexiform layer Absent
Specimen 2I, J: postnatal week 11 (more )
Note: Pane J is a higher magnification of Pane I.
Structure Level Pattern Image Note
TS28: main olfactory bulb granule cell layer Present 2I , 2J
Specimen 2K, L: postnatal week 14 (more )
Note: Pane L is a higher magnification of K.
Structure Level Pattern Image Note
TS28: caudate-putamen Present 2L , 2K
Specimen 2M: postnatal week 10 (more )
Structure Level Pattern Image Note
TS28: cerebellum Purkinje cell layer Strong 2M
TS28: cerebellum granule cell layer Strong 2M
TS28: cerebellum molecular layer Absent 2M
TS28: cerebellum white matter Absent 2M
Specimen 2N: postnatal week 11 (more )
Structure Level Pattern Image Note
TS28: cerebellum Purkinje cell layer Strong 2N
TS28: cerebellum granule cell layer Strong 2N
TS28: cerebellum molecular layer Absent 2N
TS28: cerebellum white matter Absent 2N
Specimen Table 1 E10.5: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: forelimb bud Strong Expression is stated as being strong to moderate. Expression is stated as being in skin and was coded to surface ectoderm.
TS17: gut Strong Expression is stated as being strong to moderate. Expression is stated as being in skin and was coded to surface ectoderm.
TS17: heart Strong Expression is stated as being strong to moderate. Expression is stated as being in skin and was coded to surface ectoderm.
TS17: hindlimb bud Strong Expression is stated as being strong to moderate. Expression is stated as being in skin and was coded to surface ectoderm.
TS17: midbrain Strong Expression is stated as being strong to moderate. Expression is stated as being in skin and was coded to surface ectoderm.
TS17: surface ectoderm Strong Expression is stated as being strong to moderate. Expression is stated as being in skin and was coded to surface ectoderm.
TS17: telencephalon Strong Expression is stated as being strong to moderate. Expression is stated as being in skin and was coded to surface ectoderm.
TS17: hindbrain Strong Regionally restricted Expression is stated as being strong to moderate. Expression was detected in the myelencephalon.
Specimen Table 1 E12.5: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: axial skeleton Strong Expression is stated as being strong to moderate.
TS20: gut Strong Expression is stated as being strong to moderate.
TS20: lung Strong Expression is stated as being strong to moderate.
TS20: medulla oblongata Strong Expression is stated as being strong to moderate.
TS20: midbrain Strong Expression is stated as being strong to moderate.
TS20: skin Strong Expression is stated as being strong to moderate.
TS20: spinal cord Strong Expression is stated as being strong to moderate.
TS20: telencephalon Strong Expression is stated as being strong to moderate.
TS20: heart Weak
TS20: liver Weak
TS20: spinal ganglion Weak
Specimen Table 1 E14.5: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: axial skeleton Strong Expression is stated as being strong to moderate.
TS22: lung Strong Expression is stated as being strong to moderate.
TS22: medulla oblongata Strong Expression is stated as being strong to moderate.
TS22: metanephros Strong Expression is stated as being strong to moderate.
TS22: midbrain Strong Expression is stated as being strong to moderate.
TS22: oral epithelium Strong Expression is stated as being strong to moderate.
TS22: spinal cord Strong Expression is stated as being strong to moderate.
TS22: spinal ganglion Strong Expression is stated as being strong to moderate.
TS22: telencephalon Strong Expression is stated as being strong to moderate.
TS22: heart Weak
TS22: liver Weak
TS22: skin Weak
Specimen Table 1 E16.5: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: lung Strong Expression is stated as being strong to moderate.
TS24: medulla oblongata Strong Expression is stated as being strong to moderate.
TS24: midbrain Strong Expression is stated as being strong to moderate.
TS24: oral epithelium Strong Expression is stated as being strong to moderate.
TS24: skin Strong Expression is stated as being strong to moderate.
TS24: spinal cord Strong Expression is stated as being strong to moderate.
TS24: spinal ganglion Strong Expression is stated as being strong to moderate.
TS24: telencephalon Strong Expression is stated as being strong to moderate.
TS24: axial skeleton Weak
TS24: gut Weak
TS24: heart Weak
TS24: liver Weak
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
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