Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Isg15tm1Kpk
Name:	ISG15 ubiquitin-like modifier; targeted mutation 1, Klaus-Peter Knobeloch
MGI ID:	MGI:3586990
Synonyms:	ISG15-
Gene:	Isg15  Location: Chr4:156283912-156285253 bp, - strand  Genetic Position: Chr4, 88.61 cM
Alliance:	Isg15tm1Kpk page

Germline Transmission:	Earliest citation of germline transmission: J:100028
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A floxed PGK-neo cassette replaced the complete coding region. Northern blot of mutant bone marrow failed to detect transcript. Western blot failed to detect protein in mutants. (J:100028)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	12 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Isg15 Mutation:	18 strains or lines available

Original:	J:100028 Osiak A, et al., ISG15, an interferon-stimulated ubiquitin-like protein, is not essential for STAT1 signaling and responses against vesicular stomatitis and lymphocytic choriomeningitis virus. Mol Cell Biol. 2005 Aug;25(15):6338-45
All:	30 reference(s)