Tg(Ins2-OVA)59Wehi Transgene Detail MGI Mouse (MGI:3583258)

Tg(Ins2-OVA)59Wehi
Transgene Detail

Summary

Symbol:	Tg(Ins2-OVA)59Wehi
Name:	transgene insertion 59, Walter and Eliza Hall Institute of Medical Research
MGI ID:	MGI:3583258
Synonyms:	RIP-OVA^hi, RIP-sOVA
Transgene:	Tg(Ins2-OVA)59Wehi Location: unknown
Alliance:	Tg(Ins2-OVA)59Wehi page

Transgene
origin

Strain of Origin:

B6.C-H2^bm1/ByJWehi

Transgene
description

Transgene Type:

Transgenic (Inserted expressed sequence)

Mutation:

Insertion

Tg(Ins2-OVA)59Wehi expresses 1 gene

Mutation details: Mice bearing this transgene express a secreted form of ovalbumin from the full-length chicken ovalbumin cDNA under control of the rat insulin 2 promoter. (J:99451)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

The pancreatic islets of transgenic mice exhibit weak ovalbumin- (OV-) specific immunohistologic staining. Western blot analysis measures the islet OV content as 1.0 +/- 0.4 ng/'ug of protein. These mice develop diabetes following adoptive transfer of activated, but not naive, CD8+ T lymphocytes from mice bearing Tg(TcraTcrb)1100Mjb (OT-1).

References

Original:	J:99560 Kurts C, et al., Major histocompatibility complex class I-restricted cross-presentation is biased towards high dose antigens and those released during cellular destruction. J Exp Med. 1998 Jul 20;188(2):409-14
All:	22 reference(s)

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