Phenotypes associated with this allele

• Allele Symbol: Tg(Ins2-OVA)59Wehi
• Allele Name: transgene insertion 59, Walter and Eliza Hall Institute of Medical Research
• Allele ID: MGI:3583258
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Ins2-OVA)59Wehi/?	involves: BALB/c * C57BL/6	MGI:3789286

Genotype
MGI:3789286

tg1

• Allelic Composition: Tg(Ins2-OVA)59Wehi/?
• Genetic Background: involves: BALB/c * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal T cell activation ( J:99560 )

• OVA specific OT-I T cells become activated and proliferate when transferred to into this mouse strain

increased susceptibility to autoimmune diabetes ( J:99560 )

• mice die from diabetes within 8 days of transfer of OVA-specific CD8 T cells

endocrine/exocrine glands

abnormal pancreatic beta cell physiology ( J:99560 )

• beta cells secrete detectable amounts of a soluble form of chicken ovalbumin (OVA)

hematopoietic system

abnormal T cell activation ( J:99560 )

• OVA specific OT-I T cells become activated and proliferate when transferred to into this mouse strain