Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Syngap1tm1Grnt
Name:	synaptic Ras GTPase activating protein 1 homolog (rat); targeted mutation 1, Seth G N Grant
MGI ID:	MGI:3580631
Synonyms:	SynGAP-
Gene:	Syngap1  Location: Chr17:27160227-27191408 bp, + strand  Genetic Position: Chr17, 13.6 cM
Alliance:	Syngap1tm1Grnt page

Germline Transmission:	Earliest citation of germline transmission: J:98903
Parent Cell Line:	E14TG2a (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: The exons encoding the C2 and GAP domains were replaced with a vector containing an IRES-lacZ-pA and a MC1-neo-pa cassette. Immunoblot demonstrated mutants had decreased levels of protein. (J:98903)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Syngap1 Mutation:	49 strains or lines available

Original:	J:98903 Komiyama NH, et al., SynGAP regulates ERK/MAPK signaling, synaptic plasticity, and learning in the complex with postsynaptic density 95 and NMDA receptor. J Neurosci. 2002 Nov 15;22(22):9721-32
All:	7 reference(s)