All Phenotypes Syngap1<tm1Grnt> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Syngap1^tm1Grnt
targeted mutation 1, Seth G N Grant
MGI:3580631

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Syngap1^tm1Grnt/Syngap1^tm1Grnt	involves: 129P2/OlaHsd * MF1	MGI:3581299
ht2	Syngap1^tm1Grnt/Syngap1⁺	involves: 129P2/OlaHsd * MF1	MGI:3581300
cx3	Hras^tm1Grnt/Hras^tm1Grnt Syngap1^tm1Grnt/Syngap1⁺	involves: 129P2/OlaHsd * MF1	MGI:3581305
cx4	Dlg4^tm1Grnt/Dlg4^tm1Grnt Syngap1^tm1Grnt/Syngap1⁺	involves: 129P2/OlaHsd * MF1	MGI:3581308

Allelic Composition	Syngap1^tm1Grnt/Syngap1^tm1Grnt
Genetic Background	involves: 129P2/OlaHsd * MF1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Syngap1^tm1Grnt mutation (0 available); any Syngap1 mutation (49 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:97490 , J:98903 )

• fewer than expected homozygotes were found at P0-P2, however, PO-P2 homozygous pups were normal in size and showed no obvious breathing or feeding difficulties (J:97490)

• pups became ill at around P3-P4 and all died by P7 (J:97490)

• most died within 48 hours after birth, however they were observed to breathe and feed (J:98903)

growth/size/body

decreased body size ( J:97490 )

• P3-P4 pups were smaller than wildtype

Allelic Composition	Syngap1^tm1Grnt/Syngap1⁺
Genetic Background	involves: 129P2/OlaHsd * MF1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Syngap1^tm1Grnt mutation (0 available); any Syngap1 mutation (49 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

impaired synaptic plasticity ( J:98903 )

reduced long-term potentiation ( J:98903 )

• reduced long term potentiation in the hippocampal CA1 region (across a wide range of LTP induction protocols) in the absence of any detectable alteration in basal synaptic transmission and NMDAR-mediated synaptic currents

behavior/neurological

abnormal spatial learning ( J:98903 )

• heterozygotes initially learn slower than wildtype in spatial water maze tests, however with further training, exhibit normal learning indicating unimpaired long-term memory

Allelic Composition	Hras^tm1Grnt/Hras^tm1Grnt Syngap1^tm1Grnt/Syngap1⁺
Genetic Background	involves: 129P2/OlaHsd * MF1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hras^tm1Grnt mutation (0 available); any Hras mutation (30 available)
Syngap1^tm1Grnt mutation (0 available); any Syngap1 mutation (49 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

reduced long-term potentiation ( J:98903 )

• long term potentiation induced by 150 pulses of 5 Hz stimulation in the hippocampal CA1 region was reduced compared to wildtype and single homozygous Hras1 mutants

Allelic Composition	Dlg4^tm1Grnt/Dlg4^tm1Grnt Syngap1^tm1Grnt/Syngap1⁺
Genetic Background	involves: 129P2/OlaHsd * MF1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dlg4^tm1Grnt mutation (0 available); any Dlg4 mutation (42 available)
Syngap1^tm1Grnt mutation (0 available); any Syngap1 mutation (49 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

enhanced long-term potentiation ( J:98903 )

• 150 plulse trains of 5 Hz stimulations induced a more than twofold increase in long term potentiation (LTP) than in wildtype, which was similar to the LTP seen in single homozygous Dlgh4 mice

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