Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Plxna4tm1Matl
Name:	plexin A4; targeted mutation 1, Marc Tessier-Lavigne
MGI ID:	MGI:3579185
Synonyms:	PLA4 KO, PlexinA4-
Gene:	Plxna4  Location: Chr6:32121478-32565127 bp, - strand  Genetic Position: Chr6, 12.9 cM, cytoband B1
Alliance:	Plxna4tm1Matl page

Germline Transmission:	Earliest citation of germline transmission: J:98440
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A pgk-neomycin cassette with a 5' endoplasmic reticulum retention signal and a 3' myc epitope replaced exons 18-19, which encode the transmembrane domain. RT-PCR of mutants failed to detect transcript from 3' of the insertion in mutants. Northern blot failed to detect the truncated transcript from mutants. (J:98440)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	76 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Plxna4 Mutation:	99 strains or lines available

Original:	J:98440 Yaron A, et al., Differential requirement for Plexin-A3 and -A4 in mediating responses of sensory and sympathetic neurons to distinct class 3 Semaphorins. Neuron. 2005 Feb 17;45(4):513-23
All:	21 reference(s)