Phenotypes associated with this allele
Allelic
Composition |
Plxna4tm1Matl/Plxna4tm1Matl
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Genetic
Background |
either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CD-1) |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plxna4tm1Matl mutation
(2 available);
any
Plxna4 mutation
(99 available)
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nervous system
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• repulsive effect of Sema3A on axon growth from sensory neurons from the dorsal root ganglia was reduced compared to wildtype, with 10-20% of axons not repelled at all while the remaining axons were repelled but they fanned out broadly instead of being tightly fasciculated as in wildtype
• repulsive response of superior cervical ganglion neurons to Sema3A, but not Sema3F, was partially reduced
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• anterior commissure tract was reduced in size and defasciculated
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• the spinal sensory axons failed to form thick nerve bundles at E11.5 and showed enhanced branching at E12.5 in the limb buds
• observed a misprojecting fiber bundle along the ventral part of the paw
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• disorganized ophthalmic and maxillary projections with the ophthalmic branch overshooting beyond the normal area and some fibers leaving the main bundle to grow in different directions at E11.5, however all three projections of the trigeminal ganglion generally projected to their correct targets
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cellular
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• repulsive effect of Sema3A on axon growth from sensory neurons from the dorsal root ganglia was reduced compared to wildtype, with 10-20% of axons not repelled at all while the remaining axons were repelled but they fanned out broadly instead of being tightly fasciculated as in wildtype
• repulsive response of superior cervical ganglion neurons to Sema3A, but not Sema3F, was partially reduced
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plxna4tm1Matl mutation
(2 available);
any
Plxna4 mutation
(99 available)
|
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nervous system
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• dopaminergic amacrine cells extend aberrant processes into the S4/S5 sublamina of the inner plexiform layer unlike in wild-type mice
• calbindin+ cells extend processes into the S4/S5 sublamina of the IPL of the retina and exhibit abnormal arborization unlike in wild-type mice
• M1-type intrinsically photosensitive retinal ganglion cells (ipRGCs) exhibit aberrant dendritic arborization in the S4/S5 sublamina of the inner plexiform layer (IPL) and stratification within S1 of the IPL unlike in wild-type mice
• aberrant dopaminergic amacrine cell processes co-localize with M1-type ipRGC dendrites
• however, other subtypes of retinal ganglion and amacrine cells exhibit normal neurite arborization and neurite fasciculation of retinal cells types is normal
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• dopaminergic amacrine cells extend aberrant processes into the S4/S5 sublamina of the inner plexiform layer unlike in wild-type mice
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• M1-type intrinsically photosensitive retinal ganglion cells (ipRGCs) exhibit aberrant dendritic arborization in the S4/S5 sublamina of the inner plexiform layer (IPL) and stratification within S1 of the IPL unlike in wild-type mice
• aberrant dopaminergic amacrine cell processes co-localize with M1-type ipRGC dendrites
• however, other subtypes of retinal ganglion and amacrine cells exhibit normal neurite arborization
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vision/eye
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• dopaminergic amacrine cells extend aberrant processes into the S4/S5 sublamina of the inner plexiform layer unlike in wild-type mice
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• M1-type intrinsically photosensitive retinal ganglion cells (ipRGCs) exhibit aberrant dendritic arborization in the S4/S5 sublamina of the inner plexiform layer (IPL) and stratification within S1 of the IPL unlike in wild-type mice
• aberrant dopaminergic amacrine cell processes co-localize with M1-type ipRGC dendrites
• however, other subtypes of retinal ganglion and amacrine cells exhibit normal neurite arborization
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nervous system
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• repulsive effect of Sema3A on axon growth from sensory neurons of the dorsal root ganglia and of superior cervical ganglion neurons was eliminated
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• starting at E11.5, had severely disrupted peripheral sensory projections, with many axons crossing the dorsal midline to the other side of the body at E12.5
• peripheral sensory projections exhibited extensive outgrowth and branching as if there were no boundaries for the axons
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• severely disorganized and derasciculated ophthalmic, maxillary and mandibular projections at E11.5
• more fibers of the ophthalmic branch misprojected in different directions, and some even started to invade the eye region at E11.5 and the ophthalmic axon fibers covered the entire face, including the eyes and the fibers were thinner and heavily branched at E12.5 compared to wildtype
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• severely defasciculated even though individual axons could still be seen leaving the midbrain-hindbrain junction
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cellular
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• repulsive effect of Sema3A on axon growth from sensory neurons of the dorsal root ganglia and of superior cervical ganglion neurons was eliminated
|
nervous system
 |
• repulsive effect of Sema3A on axon growth from sensory neurons of the dorsal root ganglia and of superior cervical ganglion neurons was eliminated
|
|
|
• starting at E11.5, had severely disrupted peripheral sensory projections, with many axons crossing the dorsal midline to the other side of the body at E12.5
• peripheral sensory projections exhibited extensive outgrowth and branching as if there were no boundaries for the axons
|
|
|
• severely disorganized and derasciculated ophthalmic, maxillary and mandibular projections at E11.5
• more fibers of the ophthalmic branch misprojected in different directions, and some even started to invade the eye region at E11.5 and the ophthalmic axon fibers covered the entire face, including the eyes and the fibers were thinner and heavily branched at E12.5 compared to wildtype
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• severely defasciculated even though individual axons could still be seen leaving the midbrain-hindbrain junction
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cellular
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• repulsive effect of Sema3A on axon growth from sensory neurons of the dorsal root ganglia and of superior cervical ganglion neurons was eliminated
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nervous system
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• mice exhibit an increase in TH+ puncta in S4/S5 of the inner plexiform layer compared to in wild-type mice
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Analysis Tools