About   Help   FAQ
Slc11a2tm1Nca
Targeted Allele Detail
Summary
Symbol: Slc11a2tm1Nca
Name: solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2; targeted mutation 1, Nancy C Andrews
MGI ID: MGI:3577914
Synonyms: Slc11a2-
Gene: Slc11a2  Location: Chr15:100285779-100322090 bp, - strand  Genetic Position: Chr15, 56.29 cM
Alliance: Slc11a2tm1Nca page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:98088
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA cassette containing neomycin and cytidine deaminase flanked by loxP sites was replaced exons 6-8, which correspond to predicted transmembrane segments 3-5. (J:98088)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Slc11a2 Mutation:  38 strains or lines available
References
Original:  J:98088 Gunshin H, et al., Slc11a2 is required for intestinal iron absorption and erythropoiesis but dispensable in placenta and liver. J Clin Invest. 2005 May 2;115(5):1258-1266
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/19/2024
MGI 6.23
The Jackson Laboratory