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Drd2tm1Mok
Targeted Allele Detail
Summary
Symbol: Drd2tm1Mok
Name: dopamine receptor D2; targeted mutation 1, Motoya Katsuki
MGI ID: MGI:3576789
Synonyms: D2KO
Gene: Drd2  Location: Chr9:49251927-49319477 bp, + strand  Genetic Position: Chr9, 26.72 cM
Alliance: Drd2tm1Mok page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:97838
Parent Cell Line:  CCE/EK.CCE (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe 3' end of exon 2, containing the ATG, was replaced by a neomycin resistance gene to prevent production of either of two possible isoforms. In situ hybridization demonstrated no expression of mRNA in mutant brain samples. (J:97838)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 19 strains available      Cell Lines: 0 lines available
Carrying any Drd2 Mutation:  70 strains or lines available
References
Original:  J:97838 Yamaguchi H, et al., Dopamine D2 receptor plays a critical role in cell proliferation and proopiomelanocortin expression in the pituitary. Genes Cells. 1996 Feb;1(2):253-68
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory