Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ryr3tm1Jms
Name:	ryanodine receptor 3; targeted mutation 1, Institute of Medical Science, Japan
MGI ID:	MGI:3575753
Gene:	Ryr3  Location: Chr2:112461700-113047441 bp, - strand  Genetic Position: Chr2, 57.2 cM, cytoband E5-F3
Alliance:	Ryr3tm1Jms page

Germline Transmission:	Earliest citation of germline transmission: J:58558
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Targeting replaced a 0.85-kb segment of the gene containing parts of exons 6 and 7 with a 1.8-kb Pgk-neo cassette having stop codons in all three reading frames and a polyadenylation signal. Immunoblot analysis of microsomal fractions of the cerebra, including hippocampi, of heterozygous and homozygous mice demonstrated reduction and absence, respectively, of detectable RYR3 versus those of wild-type mice. Mice of all three genotypes expressed similar total levels of RYR proteins in their cerebra. (J:58558)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ryr3 Mutation:	261 strains or lines available

Original:	J:58558 Futatsugi A, et al., Facilitation of NMDAR-independent LTP and spatial learning in mutant mice lacking ryanodine receptor type 3. Neuron. 1999 Nov;24(3):701-13
All:	2 reference(s)