Phenotypes associated with this allele

• Allele Symbol: Ryr3^tm1Jms
• Allele Name: targeted mutation 1, Institute of Medical Science, Japan
• Allele ID: MGI:3575753
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ryr3^tm1Jms/Ryr3^tm1Jms	involves: 129P2/OlaHsd * C57BL/6J	MGI:3653887

Genotype
MGI:3653887

hm1

• Allelic Composition: Ryr3^tm1Jms/Ryr3^tm1Jms
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal spatial learning ( J:58558 )

• in a probe trial test of the Morris water maze task in which a platform is removed after the training schedule, homozygotes spend significantly more time than wild-type in the quadrant where the platform had been and tend to cross the platform site more frequently, indicating enhanced spatial learning

nervous system

enhanced long-term potentiation ( J:58558 )

• exhibit facilitated CA1 long-term potentiation (LTP) induced by short tetanus (100 Hz, 100 ms)

• LTP is not blocked by the NMDA receptor antagonist D-AP5 as in wild-type but is partially dependent on L-type voltage-dependent calcium channels (VDCCs) and metabotropic glutamate receptors (mGluRs)

absent long-term depression ( J:58558 )

• long term depression (LTD) is not induced in homozygotes