Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ly75tm1Mnz
Name:	lymphocyte antigen 75; targeted mutation 1, Michel C Nussenzweig
MGI ID:	MGI:3575119
Synonyms:	DEC-205-, DEC205 ko, DEC-205null
Gene:	Ly75  Location: Chr2:60122447-60213617 bp, - strand  Genetic Position: Chr2, 34.54 cM
Alliance:	Ly75tm1Mnz page

Germline Transmission:	Earliest citation of germline transmission: J:97292
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: A targeting vector was used to disrupt the promoter and exon 1. Flow cytometry analysis of activated T cells does not detect a functional gene product (protein). (J:97292)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ly75 Mutation:	75 strains or lines available

Original:	J:97292 Guo M, et al., A monoclonal antibody to the DEC-205 endocytosis receptor on human dendritic cells. Hum Immunol. 2000 Aug;61(8):729-38
All:	25 reference(s)