Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Slc7a7Gt(OST41878)Lex
Name:	solute carrier family 7 (cationic amino acid transporter, y+ system), member 7; gene trap OST41878, Lexicon Genetics
MGI ID:	MGI:3530880
Synonyms:	Slc7a7-, Slc7a7Gt(IRESBetageo)613Lex
Gene:	Slc7a7  Location: Chr14:54606899-54655237 bp, - strand  Genetic Position: Chr14, 27.76 cM, cytoband C1
Alliance:	Slc7a7Gt(OST41878)Lex page

Mutant Cell Line:	OST41878
Germline Transmission:	Earliest citation of germline transmission: J:125847
Parent Cell Line:	Lex-1 (ES Cell)
Strain of Origin:	129S5/SvEvBrd
Project Collection:	Lexicon

Allele Type:    Gene trapped (Null/knockout, Reporter) Mutation:    Insertion of gene trap vector   Mutation details: The gene trap vector containing a splice acceptor, beta-geo cassette and a pA was inserted into the second intron. The alteration of a transcript was confirmed by northern blot analysis on RNA extracted from kidney with probe for the two exons flanking the insertion. (J:125847) Sequence Tags:  Sequence tag details (1 tag) Tag ID GenBank ID Method Tag Location (trapped strand)* Select OST41878 CG499625 (MGI Seq Detail) 3' RACE Chr14:54612016-54612078 bp (-) * GRCm39 (strand of gene trap mutagenesis) Selected Tags: download BLAST at NCBI Genome Context:  Genome Browser view of this mutation 111 gene trap insertions have trapped this gene View all gene trap sequence tags in this region

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

6 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Slc7a7 Mutation:	78 strains or lines available

Original:	J:125847 Sperandeo MP, et al., Slc7a7 disruption causes fetal growth retardation by downregulating Igf1 in the mouse model of lysinuric protein intolerance. Am J Physiol Cell Physiol. 2007 Jul;293(1):C191-8
All:	2 reference(s)