Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Gnb1lGt(OST35527)Lex
Name:	guanine nucleotide binding protein (G protein), beta polypeptide 1-like; gene trap OST35527, Lexicon Genetics
MGI ID:	MGI:3530640
Synonyms:	Gnb1l-, Gnb1lGt(Betageo)520Lex, LEXKO-443
Gene:	Gnb1l  Location: Chr16:18317463-18385429 bp, + strand  Genetic Position: Chr16, 11.46 cM
Alliance:	Gnb1lGt(OST35527)Lex page

Mutant Cell Line:	OST35527
Germline Transmission:	Earliest citation of germline transmission: J:110101
Parent Cell Line:	Lex-1 (ES Cell)
Strain of Origin:	129S5/SvEvBrd
Project Collection:	Lexicon

Allele Type:    Gene trapped (Null/knockout, Reporter) Mutation:    Insertion of gene trap vector   Mutation details: A gene-trapping cassette inserted into intron 2, 476 base pairs upstream of exon 3, which is the first coding exon. The insertion results in aberrant splicing to the beta-galactosidase gene and loss of downstream mRNA. Sequence Tags:  Sequence tag details (1 tag) Tag ID GenBank ID Method Tag Location (trapped strand)* Select OST35527 CG495873 (MGI Seq Detail) 3' RACE Chr16:18359184-18364908 bp (+) * GRCm39 (strand of gene trap mutagenesis) Selected Tags: download BLAST at NCBI Genome Context:  Genome Browser view of this mutation 10 gene trap insertions have trapped this gene View all gene trap sequence tags in this region

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Gnb1l Mutation:	13 strains or lines available

Original:	J:110101 Paylor R, et al., Tbx1 haploinsufficiency is linked to behavioral disorders in mice and humans: implications for 22q11 deletion syndrome. Proc Natl Acad Sci U S A. 2006 May 16;103(20):7729-34
All:	4 reference(s)